DMSO: Shhh! Tell No One.

How a simple solvent discovered in 1866 threatens the entire medical industrial complex

TL;DR - The Essentials:

• A Midwestern Doctor has compiled overwhelming evidence showing DMSO could revolutionize treatment of strokes, spinal injuries, autoimmune diseases, and chronic pain

• Clinical trials reveal dramatic results: 63% of stroke patients showed marked improvement vs. 20% with standard care; 96.6% of scleroderma patients had disease progression stopped

• The compound costs $20-50 for a lifetime supply yet can replace thousands of dollars in conventional treatments - making it a threat to pharmaceutical profits

• Studies show 80-90% success rates across thousands of musculoskeletal cases, far superior to any current treatments

• DMSO is remarkably safe with over 50 years of research showing minimal side effects (mainly garlic breath) compared to dangerous alternatives like NSAIDs that kill 16,500+ Americans annually

• Current FDA tactics include regulatory capture - allowing DMSO in pharmaceutical combinations while blocking pure access to maintain control

Maybe you've spent the time perfecting your health optimization... or know it's time you should. Maybe you've tried cold therapy, red light, the perfect macros. Yet somehow, chronic issues persist. That nagging inflammation. The lingering injury from sports, your exercise routine and/or years of desk work. What about the brain fog that no amount of nootropics seem to touch.

What if the solution isn't another expensive protocol, but a simple compound discovered over 150 years ago that the medical establishment has systematically buried?

A Midwestern Doctor (AMD), @MidwesternDoc on X, the anonymous physician whose Substack has become essential reading for anyone seeking medical truth, has spent months documenting one of medicine's most suppressed healing agents: dimethyl sulfoxide (DMSO).

His research reveals something so threatening to the current paradigm that the FDA waged a multi-decade war to keep it from the public.

The Evidence They Tried to Bury

AMD's investigation into DMSO reads like a medical thriller. This naturally occurring chemical does something extraordinary - it rapidly penetrates tissue barriers, carrying healing properties directly where they're needed most. But more importantly, it works.

The clinical evidence AMD has compiled is staggering:

For Strokes: A 2002 clinical trial administered DMSO with fructose diphosphate (FDP - a metabolite cells convert to energy) intravenously twice daily to stroke patients within 12 hours of symptom onset. The results were remarkable - 63% of patients achieved 'improved' or 'markedly improved' neurological status, compared to only 20% receiving standard treatment three months later. Even more impressive: DMSO showed benefit even when given hours after the stroke, something conventional medicine considers impossible.

For Spinal Cord Injuries: AMD documents case after case where intravenous DMSO prevented paralysis. Dr. Stanley Jacob reported three patients who arrived paralyzed - one five hours post-injury, another six hours, the last nine hours after trauma. "Two of those three are now walking as a result of our administering IV DMSO," Jacob noted. This defies everything we're told about spinal cord damage being permanent.

For Autoimmune Disease: Perhaps most remarkable is AMD's documentation of scleroderma treatment. This progressive disease literally hardens skin and internal organs like saran wrap, with patients typically dying within years as organs fail from compression. Yet a Russian study of 58 scleroderma patients using 30-90% DMSO applied topically 1-2 times daily for several months to 2 years showed 96.6% had their disease progression completely stopped. Of 40 patients who completed treatment, 34 achieved complete clinical recovery, with no relapses during five years of follow-up.

The Russian patients described something medical science claims impossible: "the suddenness with which the ugly old disabilities began to disappear and the rapidity of the healing process."

The Musculoskeletal Revolution

AMD's review of the clinical literature reveals why DMSO took America by storm in the 1960s before the FDA's crackdown. The compound showed unprecedented success treating the conditions that plague millions daily.

"One of the first studies was published in 1965 and conducted by the researcher who courageously pioneered the adoption of DMSO throughout the United States":

A landmark 1967 study examined DMSO's effects across thousands of musculoskeletal cases using topical applications of varying concentrations. The results consistently showed 80-90% success rates - something dramatically better than any options available then or now, 60 years later.

"This in turn was followed by numerous 1967 studies. The largest of which found":

The study covered diverse conditions:

• Rheumatoid arthritis (chronic joint inflammation)
• Osteoarthritis (joint wear and tear)
• Bursitis (inflamed joint cushions)
• Tendonitis (inflamed connective tissues)
• Keloids (raised scars that grow beyond original wounds)
• Contractures (permanent tightening of muscles/tendons/joints)
• Post-surgical adhesions (scar tissue binding organs together after surgery)

As AMD notes, "What I am alleging here is understandably difficult to believe." The evidence is so overwhelming it challenges core assumptions about chronic disease management.

Sign up for Rabbit Hole Health

by Sleuth Wellness

Subscribe

Email sent! Check your inbox to complete your signup.

No spam. Unsubscribe anytime.

The FDA's Playbook: From DMSO to Nicotine, Same Script Different Century

"We simply cannot cope with a product like DMSO. We envision hundreds of applications coming in, and we simply don't have a budget or staff."– Robert Herschler

As we discussed in the previous addition of Rabbit Hole Health, coordinated 2030 nicotine prohibition isn't new territory for the FDA—it's the same playbook they perfected destroying DMSO in the 1960s. The parallels are so precise they read like a carbon copy operation.

In 1965, when DMSO showed miraculous results for everything from strokes to arthritis, the FDA faced the same "problem" they face with nicotine today: an unpatentable natural substance that could eliminate billions in pharmaceutical revenue. Their solution? Regulatory warfare.

First came the impossible standards. Just as they now demand double-blind trials for nicotine (knowing its characteristic odor makes blinding impossible), they demanded the same for DMSO in the 1960s. When Robert Herschler, a chemist who helped disclose the properties of dimethyl sulfoxide for FDA, told them "We simply cannot cope with a product like DMSO. We envision hundreds of applications coming in, and we simply don't have a budget or staff," the FDA chose suppression over adaptation.

The media manipulation followed identical patterns. In 1965, the FDA sent telegrams worldwide claiming DMSO could cause blindness—despite zero evidence from 100,000+ users. Today's headlines about nicotine's "dangers" echo the same false alarm playbook, weaponizing fear while ignoring mountains of contradicting evidence.

The intimidation campaign against researchers proved most effective. FDA agents raided Dr. Stanley Jacob's files—the renowned Oregon surgeon who had become DMSO's leading researcher—copying personal correspondence without permission and threatening criminal prosecution against any doctor who continued prescribing DMSO. As one FDA whistleblower revealed: "The inspectors were told to go out in the field and find some 'pigeons'... They were also very interested in finding the names of any patients who had had side effects and who would testify before congressional committees. The purpose was to try the original investigators in the press."

Sound familiar? Except for the uniquely courageous, most of today's doctors won't publicly discuss nicotine's benefits for fear of regulatory retaliation—the same chilling effect that destroyed DMSO research for decades.

Most telling was the FDA's admission of their real concern. Commissioner James Goddard stated they couldn't control DMSO because it was "both a commercial solvent and a drug" with potentially "hundreds of applications." Translation: they couldn't monopolize something so versatile and widely useful.

Nicotine faces identical suppression because it threatens the same pharmaceutical territories: antidepressants, ADHD medications, Alzheimer's treatments, anti-inflammatories, and neurodegeneration therapies worth hundreds of billions annually.

The 2030 timeline reveals the endgame. Just as DMSO prohibition removed a natural competitor before the pharmaceutical industry's expansion, nicotine prohibition clears the field before the next "pandemic" requires maximum vaccine compliance.

The FDA's war isn't about safety—it's about market control. The same agency that spent 60 years burying DMSO's miraculous healing properties now deploys identical tactics against nicotine. Different decade, same corruption, same devastating results for human health.

The Forgotten Neurological Miracle

While musculoskeletal applications made DMSO famous, its neurological effects represent perhaps the greatest medical tragedy of our time. AMD documents study after study showing DMSO's ability to protect brain and spinal cord tissue from otherwise catastrophic damage.

Animal studies demonstrated DMSO's neuroprotective effects by applying pressure sufficient to cut off brain blood supply, then administering DMSO prior to injury and every 12 hours for 3 days. DMSO proved most effective at preventing nervous tissue damage and behavioral changes, even when alcohol was present (a common factor in accidents).

A mouse study subjected animals to severe head impacts, then treated them 5 minutes later with various compounds applied topically or given systemically. DMSO-FDP combination was most protective, with DMSO alone coming second, while other treatments showed no benefit.

The human applications are even more dramatic. AMD shares the case of a Los Angeles teacher who suffered a major stroke during Christmas break. DMSO was applied topically to her head within minutes, followed by intramuscular injection within an hour. She regained consciousness the same day and returned to teaching after winter break "as if nothing had happened." She continued teaching until retirement with no disability.

The Cleveland Clinic Data

A Cleveland Clinic study of 29 scleroderma patients provided the most precise data on DMSO's mechanisms. Using radioactive isotopes to measure blood flow, researchers found with topical applications of 50% DMSO:

• 50% DMSO slightly improved circulation
• DMSO with another agent increased blood flow 1.2 times
• DMSO with 1% nicotinic acid increased blood flow 6 times

The combination also resolved Raynaud's syndrome (an autoimmune disease where blood flow to fingers/toes is restricted, causing them to turn white/blue in cold), eliminated gross edema, and completely healed finger ulcers within one month. As AMD emphasizes, this study alone should have revolutionized autoimmune treatment.

The Mechanism of Action

AMD's investigation reveals DMSO works through multiple pathways:

Cellular Protection: DMSO protects cells from otherwise fatal stressors - freezing, burning, ischemia. It stabilizes cell membranes and prevents free radical damage.

Enhanced Circulation: The compound improves blood flow and disperses clumped blood cells that disrupt microcirculation.

Anti-Inflammatory Action: DMSO inhibits numerous inflammatory cytokines while promoting healing rather than just suppressing symptoms.

Protein Stabilization: Perhaps most remarkably, DMSO treats protein misfolding diseases including:

• Down Syndrome
• Amyloidosis (protein aggregates damaging organs)
• Creutzfeldt-Jakob disease (fatal brain degeneration)
• Alzheimer's and Parkinson's (neurodegenerative conditions)
• Cystic fibrosis (genetic disorder affecting lungs and digestion)

These conditions typically have no effective treatments, with drugs costing hundreds of thousands annually where they exist at all.

The Practical Protocol Guide

Understanding DMSO concentrations is crucial for safe, effective use. Based on PhD Amanda Vollmer's comprehensive protocols in her outstanding book Healing with DMSO, along with AMD's clinical guidance:

For General Topical Use (70-80% DMSO):

• 70% is optimal for most people and conditions
• 80% for maximum effectiveness on serious conditions
• Apply to clean skin, allow 5-10 minutes absorption
• Wash off residue with warm water
• Caution: Avoid cheap, endocrine-disrupting personal care products and most, if not all, sunscreens before application

For Internal Use (20-50% DMSO):

• Maximum 50% concentration for ingestion
• Start with 1 teaspoon in water, can increase gradually
• Some require only a few drops for optimal effect
• Expect garlic breath - this confirms systemic absorption

For Eye/Ear Applications (20-40% DMSO):

• Start with 20% in distilled water or normal saline
• Can progress to 40% for stubborn conditions
• Apply 2-3 drops 1-2 times daily
• Critical warning: Skin must be completely clean - DMSO will transport any substance (including toxic lotions, fragrances, or sunscreens) deep into tissue

Dr. James Miller's clinical experience with DMSO provides additional insights in his interview with Maria Zeee where he details specific protocols for conditions ranging from stroke recovery to chronic pain management.

A close follower of AMD's work, this doctor, a trauma surgeon turned primary care physician, does absolutely no boosting of his presence via social media, newsletters, etc., yet patients see him every day for a host of different issues. And here I thought I was practically anonymous on the interwebs! Well, allow me to do some boosting for Miller today to my rather exclusive, but growing, readership.

He describes one case of a severely bipolar patient with kidney stones that warranted surgery; fear of going under the knife, compounded by his psychological disorder, made the procedure a non-starter for him. After Miller used DMSO to dissolve the stones, this man was actually able to reduce his psych meds too. Coincidence?

One of his more remarkable takes was that patients don't have to stay on it for life. It repairs damage and doesn't need continuation after an issue is resolved. As he states in the interview, "It fixes the actual problem."

Easy Protocol:

For just about anything, Dr. Miller recommends two weeks of topical use in the most affected area. If the improvement needle still isn't moving enough, he moves to oral dosage. The main side-effect for either method–smelling like garlic.

According to Miller's experience, to get a poisonous dose when ingested would require 100X the maximum dose (like drinking a whole bottle in a short amount of time). Pragmatically, it's very hard to hurt yourself with DMSO.

For systemic autoimmune diseases, lupus for example, he gives 1 teaspoon of DMSO in a little orange juice and adds that it doesn't even have to be taken every day. He never uses more than a tablespoon because the massive repolarizing effect the substance has on cells can be unpleasant.

Watch this...

Beyond Individual Healing

AMD notes he's now received "hundreds of often unbelievable reports" from readers whose lives were transformed by DMSO. Pierre Kory, the physician famous for COVID treatment protocols, has shifted his practice to focus on DMSO after reviewing the evidence.

The grassroots movement is building. DMSO articles have been seen by millions, and colleagues report patients asking about it for the first time in decades.

Drakes Takes

PhD, Lewis Drake, @LewDrakePhD on X, has compiled an 8 page document that distills a lot of DMSO knowledge and findings for both the experienced user and us noobs who want to give it a try.

Quality Sourcing Matters

AMD provides specific guidance on obtaining pharmaceutical-grade DMSO, warning of increasing counterfeit products as demand surges:

Top Recommended Sources:

• Jacob Lab - 99.98% pure, run by Stanley Jacob's son ($25-40)
• DMSO Store - 99.995% pure, most popular for internal use ($20-35)
• Nature's Gift - 99.9% pure, long-established ($15-25)
• Amanda Vollmer's Source - with added nutrients ($30-45)

Alternative Sources:

• Lewis Drake's Amazon recommendations ($15-30)
• Local farm supply stores for immediate needs (though lower purity)

Critical Requirements:

• Glass containers preferred (DMSO can leach from some plastics)
• 70% concentration ideal for beginners
• Pharmaceutical grade purity (99%+)
• Avoid sellers without established track records

The investment is minimal compared to potential benefits - these quantities typically last months to years of regular use.

The AMD Archive: Deep Dive Resources

For those ready to explore AMD's comprehensive DMSO research:

Core DMSO Series:

• DMSO Could Save Millions From Brain and Spinal Injury
• DMSO is a Miraculous Therapy for Chronic Pain
• How DMSO Treats Incurable Autoimmune Disorders
• The FDA's War Against DMSO and America
• How DMSO Cures Eye, Ear, Nose & Throat Disease
• The Remarkable History and Safety of DMSO

Advanced Applications:

• Therapeutic DMSO Combinations Revolutionize Medicine
• The Forgotten Cancer Cure Hiding in Plain Sight

Note: Many of AMD's articles contain detailed charts and graphs supporting his clinical evidence. These visual aids can be found within the original Substack posts and provide compelling data visualization of DMSO's efficacy across multiple conditions.

The Combination Therapies

Some of DMSO's most powerful applications involve combinations with other agents. AMD documents remarkable results mixing DMSO with:

• Hematoxylin: A cancer treatment showing dramatic tumor regression
• Vitamin C: Enhanced absorption protocols for immune support
• Various pharmaceuticals: Dramatically increased potency with lower doses

The compound's ability to transport other substances through tissue barriers opens entirely new therapeutic possibilities.

The Time Preference Question

The medical establishment profits from chronic disease management. Recurring revenue streams from lifetime pharmaceutical dependence. Actual healing represents a terrible business model; I know because I follow it myself. ;)

DMSO represents something different: a tool for health sovereignty. For the cost of of dinner-for-one, you can access healing potential that rivals thousands of dollars in conventional treatments.

AMD's work has created a permission structure for questioning medical orthodoxy. His documentation of clinical studies provides unassailable evidence. The protocols exist for practical implementation.

The Revolution Begins

Like other suppressed technologies, DMSO won't remain hidden forever. Bitcoin is a perfect case in point. But those who act first - who educate themselves and take responsibility for their own future - will benefit most from this revolution.

Your health stack is only as strong as its weakest link. The executive grinding 65-hour weeks while accumulating chronic inflammation. The entrepreneur optimizing everything except their cellular function. The health optimizer whose protocols aren't optimized for their unique biochemistry.

DMSO offers something rare in modern medicine: actual healing rather than symptom management. AMD's research provides the scientific foundation. The clinical evidence is overwhelming. The safety profile is exemplary.

The only question remaining is whether you're ready to investigate what has been hiding in plain sight.

As AMD concludes his series: "It is my hope that over the next few years, I will be able to do far more than I ever imagined would be possible to improve the health of humanity."

The revolution starts with information and education. It continues with individual action. And it succeeds when people reclaim their sovereignty over their own healing.

The choice is yours. But remember: they prefer you don't know about this.

Note: This newsletter is for educational purposes only and is not intended to diagnose, treat, or cure any medical condition. Always consult with qualified healthcare providers regarding any health concerns.